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Diagnostic Accuracy of Next-Generation Sequencing: Prevalence of HIV-1 Drug Resistance and Associated Factors Among Adults on Integrase Inhibitors with Virologic Failure

Emerging evidence indicates a high rate (>10%) of drug resistance (DR) associated with integrase strand transfer inhibitors (INSTIs) in developed countries, although there is limited information on DR during INSTI treatment in Uganda. With the increased use of INSTIs as standard first-line treatment...

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Huvudupphov: Sandra Lunkuse, Ronald Kiiza, Alfred Ssekagiri, Maria Nannyonjo, Nathan Ntenkaire, Faridah Nassolo, Hamida Suubi Namagembe, Faizo Kiberu, Danstan Kabuuka, Irene Andia, Joan Nakayaga Kalyango, Pauline Byakika Kibwika, Nicholas Bbosa, Pontiano Kaleebu, Deogratius Ssemwanga
Materialtyp: Artigo
Språk:Inglês
Utgiven: MDPI AG 2025-12-01
Serie:Viruses
Ämnen:
next-generation sequencing
virologic failure
high-frequency variants
minority variants
HIV-1 drug resistance
integrase strand transfer inhibitors
Länkar:https://www.mdpi.com/1999-4915/17/12/1596
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