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Discovery and optimization of marstacimab, a human monoclonal antibody targeting tissue factor pathway inhibitor for the treatment of hemophilia A and B

We report the discovery and optimization of marstacimab, a novel monoclonal antibody targeting tissue factor pathway inhibitor (TFPI), for the treatment of hemophilia A and B. Hybridoma and phage display approaches identified antibodies that blocked the TFPI: coagulation factor Xa (FXa) interaction....

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Principais autores: Macy Jin, Sunita Hett, Reema Jasuja, Swapnil Rakhe, Jatin Narula, Amy Tam, James R. Apgar, Zong Sean Juo, Lidia Mosyak, Matthew Holsti, Alison Joyce, Susan Hurst, Robert Webster, Laura Lin, Mark Stahl, Debra D. Pittman, Laird Bloom
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2026-12-01
Serier:mAbs
Fag:
Antibody optimization
developability
hemophilia, TFPI, antibody engineering
Online adgang:https://www.tandfonline.com/doi/10.1080/19420862.2026.2685362
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