Rapid and selective characterization of antibody-drug conjugates in complex sample matrices by native affinity liquid chromatography-mass spectrometry

Antibody-drug conjugates (ADCs) and other biopharmaceuticals require robust analytical methods to assess biotransformation in biological matrices. Current approaches often require off-line enrichment and extensive chromatographic separation, limiting throughput and complicating data processing. We d...

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Detalhes bibliográficos

Principais autores:	Dan Bach Kristensen, Nanna Sofie Eskesen, Clara Coll-Satue, Alexandre Nicolas, Jan Kirkeby Simonsen, Lykke Rasmussen, Trine Meiborg Sloth, Martin Ørgaard, Elizabeta Madzharova, Simon Krabbe, Katrine Zinck Leth, Pernille Foged Jensen, Alain Beck
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2026-12-01
coleção:	mAbs
Assuntos:	Antibody-drug conjugate native affinity LC-MS serum stability drug-to-antibody ratio drug-load distribution
Acesso em linha:	https://www.tandfonline.com/doi/10.1080/19420862.2026.2618314
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