The autoinflammation-associated NLRC4V341A mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice

BackgroundAutoinflammation with infantile enterocolitis (AIFEC) is an often fatal disease caused by gain-of-function mutations in the NLRC4 inflammasome. This inflammasomopathy is characterized by macrophage activation syndrome (MAS)-like episodes as well as neonatal-onset enterocolitis. Although el...

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Bibliografische Detailangaben

Hauptverfasser:	Elien Eeckhout, Tomoko Asaoka, Hanne Van Gorp, Dieter Demon, Charlotte Girard-Guyonvarc’h, Vanessa Andries, Lars Vereecke, Cem Gabay, Mohamed Lamkanfi, Geert van Loo, Andy Wullaert
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2023-11-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	NLRC4 inflammasome inflammasomopathies autoinflammation microbiota germfree mice Citrobacter rodentium
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1272639/full
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