Mitotane-Induced Hypothyroidism and Dyslipidemia in Adrenocortical Carcinoma: Sex Differences and Novel Evidence from a Thyroid Cell Model

Adrenocortical carcinoma (ACC) is a rare and aggressive cancer with limited treatment options, commonly managed with mitotane, which can cause serious side effects, including central hypothyroidism and dyslipidemia. This study aimed to evaluate the incidence, clinical features, and relationship betw...

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Autores principales:	Irene Tizianel, Arianna Beber, Alberto Madinelli, Mario Caccese, Susi Barollo, Loris Bertazza, Elena Ruggiero, Simona Censi, Caterina Mian, Filippo Ceccato
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2025-12-01
Colección:	Current Oncology
Materias:	adrenocortical carcinoma mitotane central hypothyroidism dyslipidemia thyroid cell cytotoxicity sex differences
Acceso en línea:	https://www.mdpi.com/1718-7729/32/12/700
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