Endoplasmic reticulum stress enhances fibrosis through IRE1α‐mediated degradation of miR‐150 and XBP‐1 splicing

Abstract ER stress results in activation of the unfolded protein response and has been implicated in the development of fibrotic diseases. In this study, we show that inhibition of the ER stress‐induced IRE1α signaling pathway, using the inhibitor 4μ8C, blocks TGFβ‐induced activation of myofibroblas...

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Hlavní autoři:	Femke Heindryckx, François Binet, Markella Ponticos, Krista Rombouts, Joey Lau, Johan Kreuger, Pär Gerwins
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer Nature 2016-05-01
Edice:	EMBO Molecular Medicine
Témata:	endoplasmic reticulum stress fibrosis liver cirrhosis myofibroblast scleroderma
On-line přístup:	https://doi.org/10.15252/emmm.201505925
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