Development of a Pregnancy‐Specific Physiologically Based Pharmacokinetics (PBPK) Model for Aspirin

ABSTRACT Aspirin is one of the most commonly used medications in pregnancy, particularly for the prevention of hypertensive disorders. Despite aspirin's widespread use in pregnancy for preeclampsia prevention, its pharmacokinetics (PK) across all trimesters remain poorly characterized, complicating...

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Hlavní autoři:	Ana Collins‐Smith, Ananth Kumar Kammala, Mitch A. Phelps, Xiao Ming Wang, Ramkumar Menon, Maged M. Costantine
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2026-02-01
Edice:	CPT: Pharmacometrics & Systems Pharmacology
Témata:	aspirin dose modeling PBPK pharmacokinetics
On-line přístup:	https://doi.org/10.1002/psp4.70130
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