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Regulation of GVHD and GVL Activity via PD-L1 Interaction With PD-1 and CD80

Allogeneic hematopoietic cell transplantation (HCT) is a curative therapy for hematological malignancies (i.e. leukemia and lymphoma), because graft-versus-leukemia (GVL) activity mediated by alloreactive T cells can eliminate residual malignant cells and prevent relapse. However, the same alloreact...

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Principais autores: Kaniel Cassady, Paul J. Martin, Defu Zeng
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-12-01
Serier:Frontiers in Immunology
Fag:
HCT
GVHD
alloreactive
T cell
PD-L1
PD-1
Online adgang:https://www.frontiersin.org/article/10.3389/fimmu.2018.03061/full
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