Synthetic approaches for novel fused pyrimidine derivatives: Design, structural characterization, antiviral, antitumor, and molecular docking evaluation

The goal of this work was to synthesize new compounds for anticancer evaluation as a trial to obtain new antitumor agents with higher activity and fewer side effects. Therefore, the precursor 2,2'-(1,4-phenylenebis (thiazole-4,2-diyl))bis (3-(dimethylamino)acrylonitrile) (4) was used to synthesize v...

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Hlavní autoři:	Fatmah O. Sefrji, Abdulmajeed F. Alrefaei, Mohammed A. Imam, Gadeer R.S. Ashour, Matokah M. Abualnaja, Roba M.S. Attar, A.A.A. Darwish, Nashwa M. El-Metwaly
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2024-12-01
Edice:	Heliyon
Témata:	Thiazole Pyrimidine Antiviral Cytotoxicity Molecular docking
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2405844024169344
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