Topoisomerase IB poisons induce histone H2A phosphorylation as a response to DNA damage in Leishmania infantum
DNA topoisomerases are considered consolidated druggable targets against diseases produced by trypanosomatids. Several reports indicated that indenoisoquinolines, a family of non-camptothecinic based topoisomerase poisons, have a strong leishmanicidal effect both in vitro and in vivo in murine model...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Elsevier
2019-12-01
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| Series: | International Journal for Parasitology: Drugs and Drug Resistance |
| Acceso en liña: | http://www.sciencedirect.com/science/article/pii/S2211320719300818 |
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