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Overcoming methicillin resistance by methicillin-resistant Staphylococcus aureus: Computational evaluation of napthyridine and oxadiazoles compounds for potential dual inhibition of PBP-2a and FemA proteins

The treatment of the various infections caused by Staphylococcus aureus has become challenging due to the evolving resistance against current therapeutics. In this study, the potentials of napthyridine and oxadiazole derivatives to serve as dual inhibitors of penicillin-binding protein 2a (PBP-2a) a...

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Gardado en:
Principais autores: Bourhia Mohammed, Shahab Muhammad, Zheng Guojun, Taibi Mohamed, Elbouzidi Amine, Salamatullah Ahmad Mohammad, Dauelbait Musaab, Asehraou Abdeslam
Formato: Artigo
Idioma:Inglês
Publicado: De Gruyter 2024-10-01
Series:Open Chemistry
Assuntos:
methicillin-resistance
staphylococcus aureus
napthyridine compound
oxadiazoles compound
pbp-2a protein
fema protein
Acceso en liña:https://doi.org/10.1515/chem-2024-0082
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