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Repeated Administration of Norbinaltorphimine Produces Cumulative Kappa Opioid Receptor Inactivation

Kappa receptor activation by dynorphins contributes to the anxiogenic, dysphoric, and cognitive disrupting effects of repeated stress, suggesting that kappa receptor antagonists might have therapeutic utility in the treatment of stress disorders. Three classes of kappa antagonists have been distingu...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Charles Chavkin, Joshua H. Cohen, Benjamin B. Land
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2019-02-01
Cyfres:Frontiers in Pharmacology
Pynciau:
Mynediad Ar-lein:https://www.frontiersin.org/article/10.3389/fphar.2019.00088/full
Tagiau: Ychwanegu Tag
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