Rft1 catalyzes lipid-linked oligosaccharide translocation across the ER membrane
Abstract The eukaryotic asparagine (N)-linked glycan is pre-assembled as a fourteen-sugar oligosaccharide on a lipid carrier in the endoplasmic reticulum (ER). Seven sugars are first added to dolichol pyrophosphate (PP-Dol) on the cytoplasmic face of the ER, generating Man5GlcNAc2-PP-Dol (M5GN2-PP-D...
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| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Portfolio
2024-06-01
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| Series: | Nature Communications |
| Acceso en liña: | https://doi.org/10.1038/s41467-024-48999-3 |
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