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Identification and Analysis of Small Molecule Inhibitors of CRISPR-Cas9 in Human Cells

Genome editing tools based on CRISPR–Cas systems can repair genetic mutations in situ; however, off-target effects and DNA damage lesions that result from genome editing remain major roadblocks to its full clinical implementation. Protein and chemical inhibitors of CRISPR–Cas systems may reduce off-...

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Principais autores: Yue Yang, Donghua Li, Fen Wan, Bohong Chen, Guanglan Wu, Feng Li, Yanliang Ren, Puping Liang, Jian Wan, Zhou Songyang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-11-01
Colecção:Cells
Assuntos:
CRISPR
gene-editing
small molecule inhibitor
SpCas9
off-target
Acesso em linha:https://www.mdpi.com/2073-4409/11/22/3574
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