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Differential Expression of <i>HOX</i> Genes in Mesenchymal Stem Cells from Osteoarthritic Patients Is Independent of Their Promoter Methylation

Skeletogenesis, remodeling, and maintenance in adult tissues are regulated by sequential activation of genes coding for specific transcription factors. The conserved Homeobox genes (<i>HOX</i>, in humans) are involved in several skeletal pathologies. Osteoarthritis (OA) is characterized by homeostat...

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Principais autores: Arkaitz Mucientes, Eva Herranz, Enrique Moro, Cristina Lajas, Gloria Candelas, Benjamín Fernández-Gutiérrez, José Ramón Lamas
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2018-12-01
Serier:Cells
Fag:
osteoarthritis (OA)
cartilage
bone
<i>HOX</i>
homeobox
mesenchymal stem cells
epigenetics
methylation
Online adgang:https://www.mdpi.com/2073-4409/7/12/244
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