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Robustness of the Autophagy Pathway to Somatic Copy Number Losses

Autophagy allows cells to temporarily tolerate energy stress by replenishing critical metabolites through self-digestion, thereby attenuating the cytotoxic effects of anticancer drugs that target tumor metabolism. Autophagy defects could therefore mark a metabolically vulnerable cancer state and ope...

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Hoofdauteurs: Pierfrancesco Polo, Niklas Gremke, Thorsten Stiewe, Michael Wanzel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2022-05-01
Reeks:Cells
Onderwerpen:
autophagy
cancer metabolism
aerobic glycolysis
somatic copy number alterations (SCNAs)
copy number loss
haploinsufficiency
Online toegang:https://www.mdpi.com/2073-4409/11/11/1762
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