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Sex differences and the role of estrogens in the immunological underpinnings of Alzheimer's disease

Abstract Alzheimer's disease (AD) affects women more frequently and more severely than men, but the biological mechanisms underlying these sex differences remain poorly understood. This review integrates recent findings from neuroscience, immunology, endocrinology, and genetics to explore how sex st...

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Principais autores: Brittani R. Price, Keenan A. Walker, Jaclyn M. Eissman, Vidyani Suryadevara, Lindsey N. Sime, Timothy J. Hohman, Marcia N. Gordon
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2025-07-01
Serier:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Fag:
adaptive immunity
apolipoprotein E
astrocytes
cognitive decline
estradiol
estrogen
Online adgang:https://doi.org/10.1002/trc2.70139
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