TDP-43 dysfunction leads to bioenergetic failure and lipid metabolic rewiring in human cells

The dysfunction of TAR DNA-binding protein 43 (TDP-43) is implicated in various neurodegenerative diseases, though the specific contributions of its toxic gain-of-function versus loss-of-function effects remain unclear. This study investigates the impact of TARDBP loss on cellular metabolism and via...

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Bibliografiske detaljer

Principais autores:	Miriam Ceron-Codorniu, Pascual Torres, Anna Fernàndez-Bernal, Santiago Rico-Rios, José CE. Serrano, Maria P. Miralles, Maria Beltran, Ana Garcera, Rosa M. Soler, Reinald Pamplona, Manuel Portero-Otín
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2024-09-01
Serier:	Redox Biology
Fag:	Amyotrophic lateral sclerosis ACSL4 TDP-43 In vitro models Homeostasis
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2213231724002799
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