Dose Optimization for Single Intradiscal Administration of the Tumor Necrosis Factor-α Inhibitor, Etanercept, in Rat Disc Injury Models

Study DesignExperimental animal study.PurposeWe aimed to determine the optimal dose of a single direct injection of the tumor necrosis factor (TNF)-α inhibitor, etanercept, by using the rat model of degenerative intervertebral disc from injury.Overview of LiteratureThe pain-related peptide expressio...

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Bibliografische Detailangaben

Hauptverfasser:	Kazuhide Inage, Sumihisa Orita, Kazuyo Yamauchi, Takane Suzuki, Miyako Suzuki, Yoshihiro Sakuma, Go Kubota, Yasuhiro Oikawa, Takeshi Sainoh, Jun Sato, Kazuki Fujimoto, Yasuhiro Shiga, Koki Abe, Hirohito Kanamoto, Masahiro Inoue, Hideyuki Kinoshita, Kazuhisa Takahashi, Seiji Ohtori
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Korean Spine Society 2016-08-01
Schriftenreihe:	Asian Spine Journal
Schlagworte:	Degenerative intervertebral disc Tumor necrosis factor-alpha Etanercept Dose Optimization
Online-Zugang:	http://www.asianspinejournal.org/upload/pdf/asj-10-619.pdf
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