The JAK1/2 Inhibitor Baricitinib Mitigates the Spike-Induced Inflammatory Response of Immune and Endothelial Cells In Vitro

The purpose of this study was to examine the effect of the JAK-STAT inhibitor baricitinib on the inflammatory response of human monocyte-derived macrophages (MDM) and endothelial cells upon exposure to the spike S1 protein from SARS-CoV-2. The effect of the drug has been evaluated on the release of...

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Главные авторы:	Amelia Barilli, Rossana Visigalli, Francesca Ferrari, Giulia Recchia Luciani, Maurizio Soli, Valeria Dall’Asta, Bianca Maria Rotoli
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2022-09-01
Серии:	Biomedicines
Предметы:	baricitinib chemokines COVID-19 endothelium immune innate cells JAK-STAT
Online-ссылка:	https://www.mdpi.com/2227-9059/10/9/2324
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