Cyclin D1 overexpression induces replication stress and microhomology-mediated end-joining dependence in mantle cell lymphoma

Oncogene expression can cause replication stress (RS), leading to DNA double-strand breaks (DSBs) that require repair through pathways such as homologous recombination, nonhomologous end-joining, and microhomology-mediated end-joining (MMEJ). Cyclin D1 (encoded by CCND1) is a well-known oncoprotein...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Jithma P. Abeykoon, Shuhei Asada, Guangli Zhu, Yuna Hirohashi, Lisa Moreau, Divya Iyer, Sirisha Mukkavalli, Kalindi Parmar, Gabriella Zambrano, Lige Jiang, Dongni Yi, Michelle Manske, Kimberly Gwin, Rebecca L. King, James R. Cerhan, Xiaosheng Wu, Zhenkun Lou, Geoffrey I. Shapiro, Thomas Witzig, Alan D’Andrea
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Clinical Investigation 2025-09-01
Serija:	The Journal of Clinical Investigation
Teme:	Cell biology Hematology
Online dostop:	https://doi.org/10.1172/JCI193006
Oznake:	Označite Brez oznak, prvi označite!