Neutralization Epitopes in Trimer and Pentamer Complexes Recognized by Potent Cytomegalovirus-Neutralizing Human Monoclonal Antibodies

ABSTRACT Human cytomegalovirus (HCMV) infects 36% to almost 100% of adults and causes severe complications only in immunocompromised individuals. HCMV viral surface trimeric (gH/gL/gO) and pentameric (gH/gL/UL128/UL130/UL131A) complexes play important roles in HCMV infection and tropism. Here, we is...

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Detalhes bibliográficos

Principais autores:	Yuanbao Ai, Changwen Wu, Ming Zhang, Dabbu Kumar Jaijyan, Tong Liu, Lipeng Zan, Nan Li, Wei Yu, Yueming Wang, Xiaohui Yuan, Chengming Li, Weihong Zheng, Hua Zhu, Hua-Xin Liao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2022-12-01
Colecção:	Microbiology Spectrum
Assuntos:	human cytomegalovirus pentamer complex gH/gL/gO neutralizing antibodies therapeutics gH/gL reactive
Acesso em linha:	https://journals.asm.org/doi/10.1128/spectrum.01393-22
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