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A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine

Abstract We developed a new chimeric M2e and H3 hemagglutinin (HA) stalk protein vaccine (M2e-H3 stalk) by genetic engineering of modified H3 stalk domain conjugated with conserved M2e epitopes to overcome the drawbacks of low efficacy by monomeric domain-based universal vaccines. M2e-H3 stalk prote...

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Bibliografische gegevens
Hoofdauteurs: Jeeva Subbiah, Judy Oh, Ki-Hye Kim, Chong-Hyun Shin, Bo Ryoung Park, Noopur Bhatnagar, Baik-Lin Seong, Bao-Zhong Wang, Sang-Moo Kang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Portfolio 2022-06-01
Reeks:npj Vaccines
Online toegang:https://doi.org/10.1038/s41541-022-00498-6
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