Exogenous 8-Hydroxydeoxyguanosine Attenuates PM_2.5-Induced Inflammation in Human Bronchial Epithelial Cells by Decreasing NLRP3 Inflammasome Activation

Particulate matter 2.5 (PM_2.5) induces lung injury by increasing the generation of reactive oxygen species (ROS) and inflammation. ROS aggravates NLRP3 inflammasome activation, which activates caspase-1, IL-1β, and IL-18 and induces pyroptosis; these factors propagate inflammation. In con...

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Principais autores:	Jihye Bang, Kuk Hui Son, Hye-Ryeon Heo, Eunsook Park, Hyun-Jeong Kwak, Kyung-Ok Uhm, Myung-Hee Chung, Young-Youl Kim, Hyun Joung Lim
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2023-05-01
Serija:	Antioxidants
Teme:	particulate matter 2.5 lung injury reactive oxygen species 8-hydroxydeoxyguanosine NLRP3 inflammasome
Online dostop:	https://www.mdpi.com/2076-3921/12/6/1189
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