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Evolution-based mathematical models significantly prolong response to abiraterone in metastatic castrate-resistant prostate cancer and identify strategies to further improve outcomes

Background: Abiraterone acetate is an effective treatment for metastatic castrate-resistant prostate cancer (mCRPC), but evolution of resistance inevitably leads to progression. We present a pilot study in which abiraterone dosing is guided by evolution-informed mathematical models to delay onset of...

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Principais autores: Jingsong Zhang, Jessica Cunningham, Joel Brown, Robert Gatenby
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2022-06-01
Serier:eLife
Fag:
cancer evolution
metastatic prostate cancer
mathematical models
adaptive therapy
Online adgang:https://elifesciences.org/articles/76284
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