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Histidinol dehydrogenase (HisD): a critical regulator of Staphylococcus aureus virulence and a promising target for antivirulence therapy

ABSTRACT Staphylococcus aureus is a pathogen responsible for diverse severe infections. The global spread of methicillin-resistant S. aureus (MRSA) necessitates innovative therapeutic approaches beyond traditional antibiotics. S. aureus virulence mechanisms remain a critical concern. Targeting histi...

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Principais autores: Wenwen Jiang, Haotian Chen, Zejing Liu, Yingqiang Dang, Yichen Da, Zhenhua Liu, Yuyan Zhu, Lina Gao, Wenjin Yan, Jian Han, Chongge You
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2026-01-01
Serier:Microbiology Spectrum
Fag:
Staphylococcus aureus
virulence
biofilm
hisD
histidinol dehydrogenase
pixantrone
Online adgang:https://journals.asm.org/doi/10.1128/spectrum.01429-25
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