Enhancement of polymyxin B1 production by an artificial microbial consortium of Paenibacillus polymyxa and recombinant Corynebacterium glutamicum producing precursor amino acids

Polymyxin B, produced by Paenibacillus polymyxa, is used as the last line of defense clinically. In this study, exogenous mixture of precursor amino acids increased the level and proportion of polymyxin B1 in the total of polymyxin B analogs of P. polymyxa CJX518-AC (PPAC) from 0.15 g/L and 61.8 % t...

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Váldodahkkit:	Hui-Zhong Sun, Si-Yu Wei, Qiu-Man Xu, Wei Shang, Qing Li, Jing-Sheng Cheng, Ying-Jin Yuan
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	KeAi Communications Co., Ltd. 2024-03-01
Ráidu:	Synthetic and Systems Biotechnology
Fáttát:	Polymyxin Co-culture Paenibacillus polymyxa Corynebacterium glutamicum Medium optimization Metabolic precursors
Liŋkkat:	http://www.sciencedirect.com/science/article/pii/S2405805X24000152
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