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Differential and organ-specific functions of organic solute transporter α and β in experimental cholestasis

Background & Aims: Organic solute transporter (OST) subunits OSTα and OSTβ facilitate bile acid efflux from the enterocyte into the portal circulation. Patients with deficiency of OSTα or OSTβ display considerable variation in the level of bile acid malabsorption, chronic diarrhea, and signs of...

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Principais autores: Sandra M.W. van de Wiel, Begoña Porteiro, Saskia C. Belt, Esther W.M. Vogels, Isabelle Bolt, Jacqueline L.M. Vermeulen, D. Rudi de Waart, Joanne Verheij, Vanesa Muncan, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2022-05-01
Serier:JHEP Reports
Fag:
ASBT
NTCP
BSEP
Cholestasis
SLC51A
diarrhea
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589555922000350
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