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Collagen-derived dipeptide prolyl-hydroxyproline promotes osteogenic differentiation through Foxg1

Abstract Prolyl-hydroxyproline (Pro-Hyp) is one of the major constituents of collagen-derived dipeptides. We previously reported that Pro-Hyp promotes the differentiation of osteoblasts by increasing Runx2, osterix and Col1α1 mRNA expression levels. Here, to elucidate the mechanism of Pro-Hyp promot...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Yoshifumi Kimira, Haruka Odaira, Kaho Nomura, Yuri Taniuchi, Naoki Inoue, Sachie Nakatani, Jun Shimizu, Masahiro Wada, Hiroshi Mano
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2017-12-01
Schriftenreihe:Cellular & Molecular Biology Letters
Schlagworte:
Prolyl-hydroxyproline
Collagen peptide
Osteoblast differentiation
Foxo1
Foxg1
Online-Zugang:http://link.springer.com/article/10.1186/s11658-017-0060-2
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