Induction of immune education in type 1 diabetes through controlled allogeneic islet rejection at onset: a monocentric open-label pilot studyResearch in context

Summary: Background: Current immunotherapies for type 1 diabetes (T1D) have shown limited success in durably preserving β-cell function. We tested a novel strategy that repurposes allogeneic islet transplantation not for metabolic replacement, but as a platform for antigen-specific immune education...

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Główni autorzy:	Lorenzo Piemonti, Andrea Mario Bolla, Amelia Caretto, Raffaella Melzi, Alessia Mercalli, Valeria Sordi, Paolo Monti, Paola Magistretti, Vito Lampasona, Ilaria Marzinotto, Paola Maffi, Miriam Ramondetta, Nicoletta Cagni, Erica Pedone, Davide Catarinella, Massimo Cardillo, Rossana Caldara, Emanuele Bosi
Format:	Artigo
Język:	Inglês
Wydane:	Elsevier 2025-12-01
Seria:	EClinicalMedicine
Hasła przedmiotowe:	Type 1 diabetes (T1D) Immunotherapy β-cell function preservation Allogeneic islet transplantation Antigen-specific immune education Minimal islet mass
Dostęp online:	http://www.sciencedirect.com/science/article/pii/S2589537025006194
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