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Nitric oxide synthase and intermittent hypoxia-induced spatial learning deficits in the rat

Intermittent hypoxia (IH) during sleep induces significant neurobehavioral deficits in the rat. Since nitric oxide (NO) has been implicated in ischemia-reperfusion-related pathophysiological consequences, the temporal effects of IH (alternating 21% and 10% O2 every 90 s) and sustained hypoxia (SH; 1...

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Principais autores: Richard C. Li, Barry W. Row, Leila Kheirandish, Kenneth R. Brittian, Evelyne Gozal, Shang Z. Guo, Leroy R. Sachleben, Jr, David Gozal
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2004-10-01
coleção:Neurobiology of Disease
Assuntos:
iNOS
eNOS
nNOS
Intermittent hypoxia
Neurobehavioral deficits
Knockout mice
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0969996104001238
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