DNMT3a Downregulation Ttriggered Upregulation of GABAA Receptor in the mPFC Promotes Paclitaxel‐Induced Pain and Anxiety in Male Mice

Abstract Chemotherapeutic agents, such as paclitaxel (PTX), induce neuroplastic changes and alter gene expression in the prefrontal cortex (PFC), which may be associated with chemotherapy‐induced pain and negative emotions. Notably, DNA methylation undergoes adaptive changes in neurological disorder...

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Detalhes bibliográficos

Principais autores:	Lixia Tian, Xu‐Hui Li, Yu‐Long Zhao, Hui‐Yuan Yi, Xue‐Ru Liu, Rongrong Yao, Xue‐Mei Hou, Xuan Zhu, Fu‐Quan Huo, Tao Chen, Lingli Liang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2025-02-01
coleção:	Advanced Science
Assuntos:	anxiety DNMT3a GABAA receptor paclitaxel neuropathic pain
Acesso em linha:	https://doi.org/10.1002/advs.202407387
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