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Induced Synthesis of Mycolactone Restores the Pathogenesis of Mycobacterium ulcerans In Vitro and In Vivo

Mycobacterium ulcerans is the causative agent of Buruli ulcer (BU), the third most common mycobacterial infection. Virulent M. ulcerans secretes mycolactone, a polyketide toxin. Most observations of M. ulcerans infection are described as an extracellular milieu in the form of a necrotic ulcer. While...

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Principais autores: Emily Strong, Bryan Hart, Jia Wang, Maria Gonzalez Orozco, Sunhee Lee
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-03-01
Serier:Frontiers in Immunology
Fag:
Buruli ulcer
mycobacteria
macrophages
mycolactone
host–microbe interaction
cytotoxicity
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2022.750643/full
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