OCT4 and PAX6 determine the dual function of SOX2 in human ESCs as a key pluripotent or neural factor

Abstract Background Sox2 is a well-established pluripotent transcription factor that plays an essential role in establishing and maintaining pluripotent stem cells (PSCs). It is also thought to be a linage specifier that governs PSC neural lineage specification upon their exiting the pluripotent sta...

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Autors principals:	Shuchen Zhang, Emma Bell, Huihan Zhi, Sarah Brown, Siti A. M. Imran, Véronique Azuara, Wei Cui
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2019-04-01
Col·lecció:	Stem Cell Research & Therapy
Matèries:	SOX2 OCT4 PAX6 Neural differentiation Human embryonic stem cells
Accés en línia:	http://link.springer.com/article/10.1186/s13287-019-1228-7
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