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Hereditary diffuse gastric and lobular breast cancer syndrome associated with germline CDH1 variants: focus on lobular breast cancer

Abstract Background Hereditary lobular breast cancer (HLBC) is a distinct subset of hereditary breast cancer primarily associated with germline pathogenic variants in the CDH1 gene, which encodes E-cadherin, a crucial protein in cell adhesion. Loss of E-cadherin disrupts tissue architecture, contrib...

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Principais autores: Giovanni Corso, Francesca Magnoni, Giorgio Bogani, Paolo Veronesi, Viviana Galimberti, Adriana Albini
Format: Artigo
Sprog:Inglês
Udgivet: Springer 2025-05-01
Serier:Journal of Cancer Research and Clinical Oncology
Fag:
Hereditary lobular breast cancer
CDH1 gene
Genetic screening
E-cadherin
IGCLC guidelines
Online adgang:https://doi.org/10.1007/s00432-025-06222-w
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