Treatment of male and female spontaneously hypertensive rats with TNF-α inhibitor etanercept increases markers of renal injury independent of an effect on blood pressure
Highlights Etanercept treatment successfully decreased renal TNF-α levels in male and female SHR. Inhibition of TNF-α did not alter BP in SHR of either sex. Inhibition of TNF-α significantly elevated creatinine and KIM-1 levels in both male and female SHR, indicating TNF-α may be necessary for maint...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BMC
2022-04-01
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| Collection: | Biology of Sex Differences |
| Sujets: | |
| Accès en ligne: | https://doi.org/10.1186/s13293-022-00424-4 |
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