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Genomic imbalances are confined to non-proliferating cells in paediatric patients with acute myeloid leukaemia and a normal or incomplete karyotype.

Leukaemia is often associated with genetic alterations such as translocations, amplifications and deletions, and recurrent chromosome abnormalities are used as markers of diagnostic and prognostic relevance. However, a proportion of acute myeloid leukaemia (AML) cases have an apparently normal karyo...

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Principais autores: Erica Ballabio, Regina Regan, Elisa Garimberti, Jochen Harbott, Jutta Bradtke, Andrea Teigler-Schlegel, Andrea Biondi, Giovanni Cazzaniga, Giovanni Giudici, James S Wainscoat, Jacqueline Boultwood, Joanna M Bridger, Samantha J L Knight, Sabrina Tosi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2011-01-01
Serier:PLoS ONE
Online adgang:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0020607&type=printable
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