Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions.

A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative necrosis caused by the Mycobacterium ulcerans macrolide exotoxin mycolactone. Since the underlying mechanism is not known, we have investigated the effect of mycolactone on endothelial cells, focussing on the...

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Autores principales:	Joy Ogbechi, Marie-Thérèse Ruf, Belinda S Hall, Katherine Bodman-Smith, Moritz Vogel, Hua-Lin Wu, Alexander Stainer, Charles T Esmon, Josefin Ahnström, Gerd Pluschke, Rachel E Simmonds
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Public Library of Science (PLoS) 2015-07-01
Colección:	PLoS Pathogens
Acceso en línea:	http://europepmc.org/articles/PMC4504485?pdf=render
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