DEPDC5 regulates the strength of excitatory synaptic transmission by interacting with ubiquitin-specific protease 46

DEP-domain containing-5 (DEPDC5) is part of the GATOR1 complex that inhibits the mechanistic target of rapamycin complex-1 (mTORC1). Loss-of-function mutations in human DEPDC5 are the most common cause of lesional or non-lesional focal epilepsies associated with mTOR hyperactivation. Depdc5 silencin...

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Egile Nagusiak:	Maria Sabina Cerullo, Caterina Canevari, Antonella Marte, Alexandre Bacq, Antonio De Fusco, Marina Maletic, Stéphanie Baulac, Fabio Benfenati
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Elsevier 2025-08-01
Saila:	Neurobiology of Disease
Gaiak:	Depdc5 mutations DEPDC5 interactome AMPA receptors Deubiquitination Excitatory synaptic strength Primary neurons
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S0969996125002013
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