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Tetra-O-methyl-nordihydroguaiaretic acid inhibits energy metabolism and synergistically induces anticancer effects with temozolomide on LN229 glioblastoma tumors implanted in mice while preventing obesity in normal mice that consume high-fat diets.

Tetra-O-methyl-nordihydroguaiaretic acid (terameprocol; M4N), a global transcription inhibitor, in combination with a second anticancer drug induces strong tumoricidal activity and has the ability to suppress energy metabolism in cultured cancer cells. In this study, we showed that after continuous...

Бүрэн тодорхойлолт

-д хадгалсан:
Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Kotohiko Kimura, Jong Ho Chun, Yu-Ling Lin, Yu-Chuan Liang, Tiffany L B Jackson, Ru Chih C Huang
Формат: Artigo
Хэл сонгох:Inglês
Хэвлэсэн: Public Library of Science (PLoS) 2023-01-01
Цуврал:PLoS ONE
Онлайн хандалт:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0285536&type=printable
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