Time-resolved functional analysis of acute impairment of frataxin expression in an inducible cell model of Friedreich ataxia

Friedreich ataxia is a neurodegenerative disease caused by a GAA triplet repeat expansion in the first intron of the frataxin gene, which results in reduced expression levels of the corresponding protein. Despite numerous animal and cellular models, therapeutic options that mechanistically address i...

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Hlavní autoři:	Dörte Poburski, Josefine Barbara Boerner, Michel Koenig, Michael Ristow, René Thierbach
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	The Company of Biologists 2016-05-01
Edice:	Biology Open
Témata:	Frataxin Friedreich ataxia Mammalian cell model Iron sulfur cluster biosynthesis ROS HTS
On-line přístup:	http://bio.biologists.org/content/5/5/654
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