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Dual targeting of EZH1 and EZH2 for the treatment of malignant rhabdoid tumors

Malignant rhabdoid tumors (MRTs) are rare and highly aggressive pediatric cancers with no standard of care. MRTs are characterized by loss of SMARCB1, which results in upregulated expression of enhancer of zeste homolog 2 (EZH2), which is responsible for the methylation of lysine 27 of histone H3 (H...

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Principais autores: Haruka Shinohara, Rie Sawado, Makoto Nakagawa, Ayuna Hattori, Kazutsune Yamagata, Kimiharu Tauchi, Jumpei Ito, Yasumichi Kuwahara, Tsukasa Okuda, Chitose Ogawa, Issay Kitabayashi
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2022-12-01
Serier:Molecular Therapy: Oncolytics
Fag:
EZH1
EZH2
H3K27me3
malignant rhabdoid tumors (MRTs)
epigenetic drug
rare cancers
Online adgang:http://www.sciencedirect.com/science/article/pii/S2372770522001188
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