CRISPR/Cas9 uPAR Gene Knockout Results in Tumor Growth Inhibition, EGFR Downregulation and Induction of Stemness Markers in Melanoma and Colon Carcinoma Cell Lines

uPAR is a globular protein, tethered to the cell membrane by a GPI-anchor involved in several cancer-related properties and its overexpression commonly correlates with poor prognosis and metastasis. We investigated the consequences of uPAR irreversible loss in human melanoma and colon cancer cell li...

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Detalhes bibliográficos

Principais autores:	Alessio Biagioni, Anastasia Chillà, Mario Del Rosso, Gabriella Fibbi, Francesca Scavone, Elena Andreucci, Silvia Peppicelli, Francesca Bianchini, Lido Calorini, Anna Li Santi, Pia Ragno, Francesca Margheri, Anna Laurenzana
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-05-01
coleção:	Frontiers in Oncology
Assuntos:	urokinase-type plasminogen activator receptor CRISPR miR146a melanoma colon cancer
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2021.663225/full
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