CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment

Germline CTLA-4 deficiency causes severe autoimmune diseases characterized by dysregulation of Foxp3+ Tregs, hyper-activation of effector memory T cells, and variable forms autoimmune cytopenia including gradual loss of B cells. Cancer patients with severe immune-related adverse events (irAE) after...

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Detalhes bibliográficos

Principais autores:	Musleh M Muthana, Xuexiang Du, Mingyue Liu, Xu Wang, Wei Wu, Chunxia Ai, Lishan Su, Pan Zheng, Yang Liu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2023-12-01
coleção:	eLife
Assuntos:	CTLA-4 Treg-depletion B cell loss ADC Foxp3
Acesso em linha:	https://elifesciences.org/articles/87281
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