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The mismatch-repair proteins MSH2 and MSH6 interact with the imprinting control regions through the ZFP57-KAP1 complex

Abstract Background Imprinting Control Regions (ICRs) are CpG-rich sequences acquiring differential methylation in the female and male germline and maintaining it in a parental origin-specific manner in somatic cells. Despite their expected high mutation rate due to spontaneous deamination of methyl...

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Autors principals: Basilia Acurzio, Francesco Cecere, Carlo Giaccari, Ankit Verma, Rosita Russo, Mariangela Valletta, Bruno Hay Mele, Claudia Angelini, Angela Chambery, Andrea Riccio
Format: Artigo
Idioma:Inglês
Publicat: BMC 2022-08-01
Col·lecció:Epigenetics & Chromatin
Matèries:
LC–MS/MS
Chip-seq
Allele-specific analysis
CpG islands
Methyl CpG
Genomic imprinting
Accés en línia:https://doi.org/10.1186/s13072-022-00462-7
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