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Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease

Parkinson’s disease (PD) is caused by progressive neurodegeneration and characterised by motor dysfunction. Neurodegeneration of dopaminergic neurons also causes aberrations within the cortico-striato-thalamo-cortical (CSTC) circuit, which has been hypothesised to lead to non-motor symptoms such as...

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Principais autores: Nakul Ravi Raval, Frederik Gudmundsen, Morten Juhl, Ida Vang Andersen, Nikolaj Speth, Annesofie Videbæk, Ida Nymann Petersen, Jens D. Mikkelsen, Patrick MacDonald Fisher, Matthias Manfred Herth, Pontus Plavén-Sigray, Gitte Moos Knudsen, Mikael Palner
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-11-01
coleção:Frontiers in Synaptic Neuroscience
Assuntos:
Parkinson’s disease (PD)
dopamine neurodegeneration
6-OHDA = 6-hydroxydopamine
CSTC = cortico-striato-thalamo-cortical
FDG – PET
SV2A
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fnsyn.2021.715811/full
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