Deciphering the active constituents of Dabushen decoction of ameliorating osteoarthritis via PPARγ preservation by targeting DNMT1

Osteoarthritis (OA) is a multifactorial and chronic degenerative joint disease. Due to the adverse effects of currently used drugs, a safer and more effective therapy for treating OA is needed. Peroxisome proliferator-activated receptor-γ (PPARγ) is a key protein protecting cartilage. DNMT1-mediated...

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Autores principales:	Lu Qiu, Min Zhang, Chenghao Li, Yehu Hou, Hao Liu, Jia Lin, Juan Yao, Dong Zhu Duan, Yi Xi Zhang, Mi Li, Ya Ling Li, Peng Wang, Jin Tian Li, Xiao Jie Jin, Yong Qi Liu
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2022-11-01
Colección:	Frontiers in Pharmacology
Materias:	traditional Chinese medicine Dabushen decoction osteoarthritis epigenetics Dnmt1 PPARγ
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fphar.2022.993498/full
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