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Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest

The seminal description of the cellular restriction factor APOBEC3G and its antagonism by HIV-1 Vif has underpinned two decades of research on the host-virus interaction. We recently reported that HIV-1 Vif is also able to degrade the PPP2R5 family of regulatory subunits of key cellular phosphatase...

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Autores principales: Sara Marelli, James C Williamson, Anna V Protasio, Adi Naamati, Edward JD Greenwood, Janet E Deane, Paul J Lehner, Nicholas J Matheson
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications Ltd 2020-04-01
Colección:eLife
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Acceso en línea:https://elifesciences.org/articles/53036
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