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Parvovirus B19 NS1 protein induces synovitis mimicking rheumatoid arthritis

Abstract This study aims to investigate the role of parvovirus B19 infection in the pathogenesis of rheumatoid arthritis (RA). B19-NS1 DNA was cloned into the LentiORF pLEX-MCS vector, then co-transfected with the pLEX-MCS-NS1 vector and packaging system to produce LEX-NS1 lentiviral stock. LEX was...

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Principais autores: Chang-Yi Yen, Chia-Chun Tseng, Chia‐Hui Lin, Yuan‐Zhao Lin, Ruei‐Nian Li, Pin-Yi Wang, Kuan-Yu Chen, Cheng-Chin Wu, Tsan-Teng Ou, Chung-Jen Chen, Yu-Peng Liu, Jeng-Hsien Yen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2025-08-01
coleção:Scientific Reports
Assuntos:
Parvovirus B19
Rheumatoid arthritis
Synovitis
RNA-seq
Acesso em linha:https://doi.org/10.1038/s41598-025-11900-3
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