Study protocol of a randomized controlled phase II trial comparing nivolumab, ipilimumab plus radiotherapy versus nivolumab plus ipilimumab for advanced or recurrent esophageal cancer: Japan Clinical Oncology Group study JCOG2311 (ART NOUVEAU)

Abstract Background The immunogenic cell death induced by radiotherapy (RT) has been demonstrated to enhance the systemic antitumor effect of immune checkpoint inhibitors (ICIs). The incorporation of RT into ICIs has the potential to mitigate the occurrence of early treatment failure, particularly w...

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Hlavní autoři:	Katsuyuki Sakanaka, Keita Sasaki, Takahiro Tsushima, Ryunosuke Machida, Yoichi Hamai, Akinori Watanabe, Kota Kawabata, Satoru Matsuda, Ken Kato, Haruhiko Fukuda, Hiroya Takeuchi, Japan Esophageal Oncology Group of the Japan Clinical Oncology Group
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-12-01
Edice:	BMC Cancer
Témata:	Esophageal squamous cell carcinoma Nivolumab Ipilimumab Radiotherapy
On-line přístup:	https://doi.org/10.1186/s12885-025-15403-2
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